KPV

KPV is a tripeptide (lysine-proline-valine) that corresponds to the C-terminal fragment of alpha-melanocyte-stimulating hormone (α-MSH). It has been studied for anti-inflammatory activity, particularly in gastrointestinal and dermatological research models.

Mechanism

• α-MSH fragment. Derived from the last three amino acids of α-MSH; retains anti-inflammatory activity without the full peptide's effects on pigmentation.
• Cytokine modulation. Studied for reduction of pro-inflammatory cytokine signaling.

Common research protocols

Dosing information below reflects published research literature. It is not medical advice and is not a treatment plan.

• Common research use. Oral, subcutaneous, or topical.
• Frequently studied for. IBD models, skin inflammation research.

Evidence at a glance

• Animal models. Colitis and dermatitis models show reduced inflammatory infiltrate.
• Human data. Limited; primarily preclinical.

Reconstitution & handling

Lyophilized peptides ship as freeze-dried powder. Reconstitute with bacteriostatic water; refrigerate the reconstituted vial. Use the reconstitution calculator to get syringe-unit readings for your target dose. General reconstitution and syringe guidance in the How It Works page.

Primary-literature list for this guide available on request via contact.