Epitalon
Epitalon (also spelled Epithalon) is a synthetic tetrapeptide (Ala-Glu-Asp-Gly) developed by the Khavinson group in Russia. It has been studied primarily in Russian literature for effects on telomerase activity, circadian regulation, and cellular aging biomarkers.
Mechanism
- Telomerase activity. In vitro studies report upregulation of telomerase activity in somatic cells.
- Pineal / circadian effects. Studied for effects on melatonin and cortisol rhythms.
Common research protocols
Epitalon is dosed in short courses rather than continuously, and the literature splits into two distinct courses rather than one escalating schedule — a longer, lower-dose course and a shorter, heavier one. All administration is subcutaneous.
Evidence at a glance
- Human data. Small Russian clinical studies; limited replication in Western literature.
- Status. Not FDA-approved.
Reconstitution & handling
Lyophilized peptides ship as freeze-dried powder. Reconstitute with bacteriostatic water; refrigerate the reconstituted vial. Use the reconstitution calculator to get syringe-unit readings for your target dose. General reconstitution and syringe guidance in the How We Work page.
Primary-literature list for this guide available on request via contact.
Further reading — external professional sources
- Epithalon (Wikipedia spelling)
- PubMed — search "epithalon OR epitalon"
- ClinicalTrials.gov — trials for "epitalon"